Exotic Sources of Cancer Medicines: Total Synthesis of Glionitrin Natural Products (Organic Chem)
Scientists have discovered bacteria and fungi that fight each other, producing promising anti-cancer and antibiotic natural products. Join us on the journey of learning more about biology and microbes, acid mine drainage (AMD), natural product chemistry, total synthesis and organic chemistry reaction mechanisms.
Even if you are not deeply engaged with total synthesis, I am confident that this video will enrich your understanding of natural sciences.
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00:00 Introduction to Glionitrins and natural products
02:17 Acid mine drainage phenomenom and analysis of microbial phyla
05:18 Glionitrin isolation and biochemical origins
09:26 Retrosynthetic analysis, total synthesis and brief mechanistic discussions
* 5min16s – Scientists might get rich of such contaminations, but they primarily want to get rid of them 🙂
Key references:
– Total Synthesis of (−)-Glionitrin A and B Enabled by an Asymmetric Oxidative Sulfenylation of Triketopiperazines (https://pubs.acs.org/doi/10.1021/jacs.1c10364)
– Glionitrin A, an Antibiotic−Antitumor Metabolite Derived from Competitive Interaction between Abandoned Mine Microbes (https://pubs.acs.org/doi/10.1021/np800606e)
Some recommended books on organic synthesis:
– Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge)
– Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis)
– Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions)
– Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy)
– Nicolaou; Molecules That Changed the World (the world’s most important molecules and their impact on everyday life)
– Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)
